AK47 and Phoenix 350L are the best weapons in the S+ tier; these are the most lethal weapons in Back 4 Blood. The most prominent weapons in the S tier are Scar and Uzi; you can equip them along with your primary weapons.
M4 Carbine and MP5 are the best weapons in tier A, while AA12 and M16 are the best weapons in the B tier. The most prominent weapons in tier C are Ranch Rifle and 870 Express, which are just average weapons. 357 Magnum and Beretta M9 (Auto) are the best weapons in tier D.